Trichosanthes dioica has been used in tribal medicine as an anticonvulsant in north-east India since long time, but the pharmacological properties have not yet been studied. The present study investigated possible activities of the methanolic extract of Trichosanthes dioica on the central nervous system (CNS). The methanolic extract of aerial parts of Trichosanthes dioica (METD) obtained by Soxhlet extraction method was studied for its possible anticonvulsant effect. When tested in mice METD (600mg/kg) significantly reduce the lethality after 30 minutes as well as after 24 hours, and prolong the onset of convulsion to 6.6 ± 0.12 min (P < 0.05) and time to death to 26.2 ± 2.5 min (P < 0.05). This data indicates that it has some potential usefulness against the neurotoxicity which is responsible for death due to seizure produced by chemicals.
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